PLASMA-CELL-LEUKEMIA

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PLASMA-CELL-LEUKEMIA

Definition: group of clinically and biochemically diverse disorders of unknown etiology characterized by the disproportionate proliferation of one clone of B cells and the presence of a structurally and electrophoretically homogeneous (monoclonal) immunoglobulin or polypeptide subunit in serum or urine (The Merk Manual of Diagnosis and Therapy).

Conceptual Structures
ISA	MULTIPLE-MYELOMA-AND-IMMUNOPROLIFERATIVE-NEOPLASMS
SUBCLASSES	HEAVY-CHAIN-DISEASES
DESCENDANTS	HEAVY-CHAIN-DISEASES
ANCESTORS	ALL CHANGE-STATE CHANGE-STATE-ANIMAL DISEASE-EVENT EVENT HAVE-NEOPLASM LIVING-EVENT MALIGNANT-NEOPLASM MALIGNANT-NEOPLASM-BY-BODY-PART MALIGNANT-NEOPLASM-OF-LYMPHATIC-AND-HEMATOPOIETIC-TISSUE MULTIPLE-MYELOMA-AND-IMMUNOPROLIFERATIVE-NEOPLASMS PHYSICAL-EVENT
INHERITED RELATIONS	AFFECTS-PHYSIOLOGICAL-SYSTEM : PART-OF-PHYSIOLOGICAL-SYSTEM (from HAVE-NEOPLASM ) AFFECTS-TISSUE : TISSUE (from HAVE-NEOPLASM ) AGENT : ANIMAL (from LIVING-EVENT ) CAUSED-BY : CARCINOGEN (from HAVE-NEOPLASM ) DIAGNOSED-WITH : ERYTHROCYTE-SEDIMENTATION-RATE (from MULTIPLE-MYELOMA-AND-IMMUNOPROLIFERATIVE-NEOPLASMS ) DIAGNOSED-WITH-THE-USE-OF : MEDICAL-DEVICE (from DISEASE-EVENT ) EXPERIENCER : PATIENT (from DISEASE-EVENT ) HAS-RISK-FACTOR : DIET (from MALIGNANT-NEOPLASM ) LOCATION : PLACE (from PHYSICAL-EVENT ) THEME : OBJECT (from CHANGE-STATE ) TREATED-WITH : MACROBIOTIC-DIET (from MALIGNANT-NEOPLASM ) TREATED-WITH-THE-USE-OF : PHARMACEUTICAL-MATERIAL (from HAVE-NEOPLASM ) MEDICAL-DEVICE (from HAVE-NEOPLASM )
INHERITED ATTRIBUTES	DIRECTION-OF-CHANGE : NEGATIVE (from CHANGE-STATE ) POSITIVE (from CHANGE-STATE ) TYPE-OF-CHANGE : PHYSICAL (from DISEASE-EVENT ) MENTAL (from DISEASE-EVENT )